Ki Summary

Reaction Details

Report a problem with these data

Target

Gastrin-releasing peptide receptor

Ligand

BDBM50441005

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_985516 (CHEMBL2432762)

IC50

23±n/a nM

Citation

Dialer, LO; Selivanova, SV; Müller, CJ; Müller, A; Stellfeld, T; Graham, K; Dinkelborg, LM; Krämer, SD; Schibli, R; Reiher, M; Ametamey, SM Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides. J Med Chem56:7552-63 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastrin-releasing peptide receptor

Name:

Gastrin-releasing peptide receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

43214.53

Organism:

Homo sapiens (Human)

Description:

Bombesin 2 GRPR 0::P30550

Residue:

384

Sequence:

MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV

BDBM50441005

n/a

Name

BDBM50441005

Synonyms:

CHEMBL2429964

Type

Small organic molecule

Emp. Form.

C74H117FN18O13Si

Mol. Mass.

1513.9175

SMILES

CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CN(C)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccc(cc1)[Si](F)(C(C)(C)C)C(C)(C)C)C(C)C)[C@@H](O)CC(=O)N[C@@H](CC(C)C)C(N)=O |r,wU:62.72,32.45,23.24,8.15,93.97,99.102,wD:46.54,4.4,27.28,(62.15,-35.4,;62.16,-33.86,;63.49,-33.09,;60.83,-33.08,;60.83,-31.54,;59.5,-30.77,;58.17,-31.53,;58.16,-33.07,;56.84,-30.75,;56.84,-29.21,;58.18,-28.45,;58.14,-26.9,;59.59,-26.39,;60.53,-27.62,;59.65,-28.88,;55.5,-31.52,;54.17,-30.74,;54.18,-29.2,;52.83,-31.5,;51.5,-30.73,;51.51,-29.19,;50.16,-31.49,;50.16,-33.03,;48.83,-30.72,;47.5,-31.48,;46.17,-30.7,;46.17,-29.16,;44.83,-31.47,;44.8,-33,;43.5,-30.69,;42.16,-31.45,;42.15,-32.99,;40.83,-30.68,;40.84,-29.14,;42.18,-28.37,;43.66,-28.8,;44.52,-27.52,;43.57,-26.32,;43.84,-24.81,;42.67,-23.81,;41.22,-24.34,;40.96,-25.85,;42.12,-26.83,;39.49,-31.44,;38.16,-30.66,;38.17,-29.12,;36.83,-31.43,;36.82,-32.97,;38.15,-33.74,;38.14,-35.28,;39.47,-36.06,;36.81,-36.05,;35.5,-30.65,;34.16,-31.42,;34.15,-32.96,;32.83,-30.64,;31.49,-31.4,;30.16,-30.63,;28.83,-31.39,;27.5,-30.61,;26.16,-31.38,;26.15,-32.92,;24.83,-30.6,;24.84,-29.06,;26.17,-28.3,;26.18,-26.76,;27.52,-25.99,;27.52,-24.45,;28.86,-23.69,;26.19,-23.68,;23.49,-31.37,;22.16,-30.59,;22.17,-29.05,;20.82,-31.35,;19.49,-30.58,;19.51,-29.04,;18.18,-28.27,;16.85,-29.04,;16.84,-30.59,;18.17,-31.35,;15.46,-28.24,;15.45,-29.77,;14.12,-29,;12.79,-28.22,;14.1,-30.54,;12.81,-29.81,;15.44,-26.7,;16.82,-25.58,;14.09,-25.95,;15.42,-25.16,;48.84,-29.18,;50.18,-28.41,;47.51,-28.4,;62.17,-30.78,;62.18,-29.24,;63.5,-31.55,;64.84,-30.79,;64.85,-29.25,;66.17,-31.57,;67.51,-30.8,;67.51,-29.26,;68.85,-28.5,;68.86,-26.96,;70.18,-29.28,;68.84,-31.58,;70.17,-30.82,;68.83,-33.12,)|

Structure