| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hexokinase-4 |
|---|
| Ligand | BDBM50441149 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_984799 (CHEMBL2432301) |
|---|
| EC50 | 3440±n/a nM |
|---|
| Citation |  Hinklin, RJ; Boyd, SA; Chicarelli, MJ; Condroski, KR; DeWolf, WE; Lee, PA; Lee, W; Singh, A; Thomas, L; Voegtli, WC; Williams, L; Aicher, TD Identification of a new class of glucokinase activators through structure-based design. J Med Chem56:7669-78 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hexokinase-4 |
|---|
| Name: | Hexokinase-4 |
|---|
| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52175.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35557 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
|
|
|
|---|
| BDBM50441149 |
|---|
| n/a |
|---|
| Name | BDBM50441149 |
|---|
| Synonyms: | CHEMBL2430866 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15N3O2S |
|---|
| Mol. Mass. | 313.374 |
|---|
| SMILES | Cc1csc(Nc2ncccc2OCc2cccc(O)c2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
