| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50441152 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_984799 (CHEMBL2432301) |
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| EC50 | 4940±n/a nM |
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| Citation |  Hinklin, RJ; Boyd, SA; Chicarelli, MJ; Condroski, KR; DeWolf, WE; Lee, PA; Lee, W; Singh, A; Thomas, L; Voegtli, WC; Williams, L; Aicher, TD Identification of a new class of glucokinase activators through structure-based design. J Med Chem56:7669-78 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50441152 |
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| n/a |
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| Name | BDBM50441152 |
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| Synonyms: | CHEMBL2430868 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N3OS |
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| Mol. Mass. | 297.375 |
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| SMILES | Cc1csc(Nc2ncccc2OCc2ccccc2)n1 |
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| Structure | 
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