| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM50318701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_987342 (CHEMBL2438192) |
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| Ki | 1.7±n/a nM |
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| Citation |  Betschart, C; Hintermann, S; Behnke, D; Cotesta, S; Fendt, M; Gee, CE; Jacobson, LH; Laue, G; Ofner, S; Chaudhari, V; Badiger, S; Pandit, C; Wagner, J; Hoyer, D Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J Med Chem56:7590-607 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_MOUSE | Orexin receptor type 1 | Ox-1-R | Ox1-R | Ox1R |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46798.55 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_107669 |
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| Residue: | 416 |
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| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGQALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPGSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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| BDBM50318701 |
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| n/a |
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| Name | BDBM50318701 |
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| Synonyms: | CHEMBL1083659 | MK-4305 | [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23ClN6O2 |
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| Mol. Mass. | 450.921 |
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| SMILES | C[C@@H]1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2cc(Cl)ccc2o1 |r| |
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| Structure | 
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