| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50441637 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_986995 (CHEMBL2439315) |
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| Kd | 2.0±n/a nM |
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| Citation |  Zeng, Q; Rosenblum, SB; Yang, Z; Jiang, Y; McCormick, KD; Aslanian, RG; Duguma, L; Kozlowski, JA; Shih, NY; Hey, JA; West, RE; Korfmacher, WA; Berlin, M; Boyce, CW Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists. Bioorg Med Chem Lett23:6001-3 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48753.61 |
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| Organism: | GUINEA PIG |
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| Description: | HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAF
VADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCT
SSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSG
GSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGARE
AGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHSSLEHCWK
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| BDBM50441637 |
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| n/a |
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| Name | BDBM50441637 |
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| Synonyms: | CHEMBL2437430 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31F3N6O2 |
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| Mol. Mass. | 564.6013 |
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| SMILES | Nc1cc(CN2CCC(CC2)C(=O)N2CCC(CC2)n2c3ccc(F)cc3n(-c3cc(F)cc(F)c3)c2=O)ccn1 |
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| Structure | 
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