| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50442119 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_993092 (CHEMBL2446442) |
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| IC50 | 11±n/a nM |
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| Citation |  Ichikawa, M; Ohtsuka, M; Ohki, H; Ota, M; Haginoya, N; Itoh, M; Shibata, Y; Ishigai, Y; Terayama, K; Kanda, A; Sugita, K; Usui, H Discovery of DF-461, a Potent Squalene Synthase Inhibitor. ACS Med Chem Lett4:932-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50442119 |
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| n/a |
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| Name | BDBM50442119 |
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| Synonyms: | CHEMBL2441086 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28ClN5O5 |
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| Mol. Mass. | 537.995 |
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| SMILES | COc1cccc([C@H]2O[C@H](CCn3cc(cn3)C(O)=O)c3nnc(C(C)C)n3-c3ccc(Cl)cc23)c1OC |r| |
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| Structure | 
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