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TargetGlucagon-like peptide 1 receptor
LigandBDBM50442919
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1275952 (CHEMBL3090287)
IC50 36±n/a nM
Citation Heard, KR; Wu, W; Li, Y; Zhao, P; Woznica, I; Lai, JH; Beinborn, M; Sanford, DG; Dimare, MT; Chiluwal, AK; Peters, DE; Whicher, D; Sudmeier, JL; Bachovchin, WW A general method for making peptide therapeutics resistant to serine protease degradation: application to dipeptidyl peptidase IV substrates. J Med Chem56:8339-51 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucagon-like peptide 1 receptor
Name:Glucagon-like peptide 1 receptor
Synonyms:GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:Enzyme
Mol. Mass.:53035.78
Organism:Homo sapiens (Human)
Description:P43220
Residue:463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50442919
n/a
NameBDBM50442919
Synonyms:CHEMBL3086852
TypeSmall organic molecule
Emp. Form.C150H230N40O43
Mol. Mass.3281.6734
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)C(NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:69.74,77.87,89.93,113.117,119.121,146.149,42.43,28.34,19.25,8.16,175.179,194.199,222.227,2.2,wD:60.66,95.99,101.103,105.111,123.133,134.137,151.154,163.168,166.171,47.53,37.38,4.4,180.183,202.207,209.214,(52.99,-19.89,;54.32,-20.66,;54.32,-22.2,;52.99,-22.97,;55.66,-22.97,;57,-22.2,;57,-20.66,;55.66,-19.89,;58.33,-19.89,;59.66,-20.66,;59.66,-22.2,;60.99,-22.97,;60.99,-24.52,;59.66,-25.28,;58.33,-24.51,;58.33,-22.98,;58.33,-18.35,;57,-17.58,;55.66,-18.35,;57,-16.04,;58.33,-15.28,;58.33,-13.73,;59.66,-12.97,;61,-13.73,;59.66,-11.42,;55.66,-15.28,;54.33,-16.04,;54.33,-17.58,;52.99,-15.28,;52.99,-13.73,;54.33,-12.97,;54.33,-11.42,;55.65,-10.66,;55.65,-9.11,;51.66,-16.04,;50.33,-15.28,;50.33,-13.73,;48.99,-16.04,;48.99,-17.58,;47.65,-15.27,;46.32,-16.04,;46.32,-17.58,;44.99,-15.28,;44.99,-13.73,;43.65,-16.04,;43.65,-17.58,;44.99,-18.35,;42.32,-18.35,;42.32,-19.89,;43.65,-20.66,;43.65,-22.2,;42.32,-22.97,;44.99,-22.97,;40.98,-17.58,;39.65,-18.35,;39.65,-19.89,;38.32,-17.58,;36.98,-18.35,;35.64,-17.58,;35.64,-16.04,;34.31,-18.35,;34.31,-19.89,;35.64,-20.66,;35.64,-22.2,;34.31,-22.97,;36.98,-22.97,;32.98,-17.58,;31.64,-18.35,;31.64,-19.89,;30.31,-17.58,;30.31,-16.04,;31.64,-15.27,;31.64,-13.73,;32.98,-16.04,;28.98,-18.35,;28.98,-19.89,;30.31,-20.65,;27.65,-20.65,;26.31,-19.89,;24.98,-20.65,;23.64,-19.89,;22.31,-20.64,;22.3,-22.17,;20.96,-22.94,;23.64,-22.96,;24.97,-22.19,;27.65,-22.2,;28.98,-22.96,;30.31,-22.2,;28.98,-24.51,;27.65,-25.27,;26.31,-24.51,;30.31,-25.27,;30.31,-26.81,;28.98,-27.58,;31.65,-27.58,;32.98,-26.81,;32.98,-25.27,;31.65,-29.12,;32.98,-29.89,;34.32,-29.12,;32.98,-31.43,;31.65,-32.2,;30.31,-31.43,;30.31,-29.89,;28.98,-32.2,;28.98,-33.74,;30.31,-34.51,;31.65,-33.74,;30.31,-36.05,;27.65,-31.43,;26.31,-32.2,;26.31,-33.74,;24.98,-31.43,;24.98,-29.89,;26.31,-29.12,;23.65,-32.2,;22.32,-31.43,;22.32,-29.89,;20.98,-32.2,;20.98,-33.74,;19.65,-34.51,;18.32,-33.74,;19.65,-36.05,;20.98,-36.82,;20.98,-38.36,;22.31,-39.13,;22.31,-40.67,;20.98,-41.44,;19.65,-40.67,;19.65,-39.14,;18.32,-36.82,;16.98,-36.05,;16.98,-34.51,;15.64,-36.82,;14.31,-36.05,;12.98,-36.82,;12.98,-38.36,;11.65,-36.05,;11.65,-34.51,;10.32,-33.74,;10.32,-32.2,;8.98,-34.51,;7.65,-33.74,;6.31,-34.51,;6.31,-36.05,;4.98,-33.74,;4.98,-32.2,;3.64,-34.51,;2.31,-33.74,;2.31,-32.2,;.98,-34.51,;-.36,-33.74,;.98,-36.05,;-.36,-36.82,;-1.83,-36.35,;-2.79,-37.56,;-1.84,-38.77,;-.4,-38.32,;8.98,-36.05,;7.65,-36.82,;10.31,-36.82,;8.97,-37.58,;15.64,-38.36,;14.31,-39.13,;16.98,-39.13,;19.65,-31.43,;19.65,-29.89,;18.32,-32.2,;34.32,-32.2,;35.65,-31.43,;34.32,-33.74,;55.66,-24.51,;56.99,-25.28,;54.32,-25.28,;54.32,-26.82,;55.66,-27.59,;52.99,-27.59,;52.99,-29.13,;51.66,-26.82,;50.33,-27.59,;48.99,-26.82,;47.62,-27.53,;47.41,-28.96,;45.9,-29.28,;45.13,-27.94,;43.63,-27.63,;43.16,-26.16,;44.19,-25.02,;45.69,-25.34,;46.17,-26.81,;50.33,-29.13,;51.66,-29.9,;48.99,-29.9,;48.99,-31.44,;50.33,-32.2,;50.33,-33.75,;51.66,-34.51,;48.99,-34.51,;47.66,-32.2,;46.33,-31.44,;47.66,-33.74,;46.33,-34.51,;45,-33.75,;43.66,-34.51,;45,-32.2,;46.33,-36.06,;47.66,-36.82,;45,-36.82,;45,-38.37,;43.66,-39.13,;42.32,-38.37,;40.99,-39.13,;39.66,-38.37,;38.33,-39.13,;46.33,-39.13,;46.33,-40.67,;47.66,-38.36,;49,-39.13,;50.33,-38.36,;50.33,-36.82,;51.67,-39.13,;53,-38.37,;53,-36.82,;54.33,-36.06,;54.33,-34.51,;55.67,-33.75,;55.67,-32.21,;54.33,-31.44,;57,-31.44,;54.33,-39.13,;55.66,-38.36,;54.33,-40.67,)|
Structure
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