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TargetHistamine H1 receptor
LigandBDBM50443788
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1280381
Ki>2512±n/a nM
Citation Wilson DMApps JBailey NBamford MJBeresford IJBriggs MACalver ARCrook BDavis RPDavis SDean DKHarris LHeightman TDPanchal TParr CAQuashie NSteadman JGSchogger JSehmi SSStean TOTakle AKTrail BKWhite TWitherington JWorby AMedhurst AD The discovery of the benzazepine class of histamine H3 receptor antagonists. Bioorg Med Chem Lett 23:6897-901 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H1 receptor
Name:Histamine H1 receptor
Synonyms:H1R | HH1R | HISTAMINE H1 | HRH1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:55808.72
Organism:Homo sapiens (Human)
Description:Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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  Blast E-value cutoff:
BDBM50443788
n/a
NameBDBM50443788
Synonyms:CHEMBL3094213
TypeSmall organic molecule
Emp. Form.C18H28N2O
Mol. Mass.288.4277
SMILESCC(C)N1CCC(CC1)Oc1ccc2CCNCCc2c1
Structure
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