| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50328705 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1277822 (CHEMBL3097588) |
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| IC50 | 2.7±n/a nM |
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| Citation |  Meneyrol, J; Follmann, M; Lassalle, G; Wehner, V; Barre, G; Rousseaux, T; Altenburger, JM; Petit, F; Bocskei, Z; Schreuder, H; Alet, N; Herault, JP; Millet, L; Dol, F; Florian, P; Schaeffer, P; Sadoun, F; Klieber, S; Briot, C; Bono, F; Herbert, JM 5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor. J Med Chem56:9441-56 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50328705 |
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| n/a |
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| Name | BDBM50328705 |
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| Synonyms: | CHEMBL1270156 | Tanogitran |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N7O3 |
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| Mol. Mass. | 477.5587 |
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| SMILES | Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)[C@@](C)(NCC(O)=O)C(=O)N1CCCC1 |r| |
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| Structure | 
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