| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM85043 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1280009 (CHEMBL3096836) |
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| IC50 | 1180±n/a nM |
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| Citation |  Cho, JH; Jung, KY; Jung, Y; Kim, MH; Ko, H; Park, CS; Kim, YC Design and synthesis of potent and selective P2X3 receptor antagonists derived from PPADS as potential pain modulators. Eur J Med Chem70:811-30 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM85043 |
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| n/a |
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| Name | BDBM85043 |
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| Synonyms: | CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPADS |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N3O12PS2 |
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| Mol. Mass. | 511.378 |
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| SMILES | Cc1nc(N=Nc2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O |w:4.3| |
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| Structure | 
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