Reaction Details |
| Report a problem with these data |
Target | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
---|
Ligand | BDBM50444443 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1280702 (CHEMBL3097335) |
---|
IC50 | 294±n/a nM |
---|
Citation | Oka, Y; Yabuuchi, T; Oi, T; Kuroda, S; Fujii, Y; Ohtake, H; Inoue, T; Wakahara, S; Kimura, K; Fujita, K; Endo, M; Taguchi, K; Sekiguchi, Y Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase¿ inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem21:7578-83 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
---|
Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
Synonyms: | PI3-kinase subunit gamma | PI3K-gamma | PI3Kgamma | PK3CG_MOUSE | Phosphatidylinositol 3-kinase p110γ (p110γ) | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Phosphoinositide-3-kinase catalytic gamma polypeptide | Pi3kg1 | Pik3cg | PtdIns-3-kinase subunit gamma | PtdIns-3-kinase subunit p110-gamma | Serine/threonine protein kinase PIK3CG | p110gamma | p120-PI3K |
Type: | Enzyme |
Mol. Mass.: | 126411.77 |
Organism: | Mus musculus (Mouse) |
Description: | Q9JHG7 |
Residue: | 1102 |
Sequence: | MELENYEQPVVLREDNLRRRRRMKPRSAAGSLSSMELIPIEFVLPTSQRISKTPETALLH
VAGHGNVEQMKAQVWLRALETSVAAEFYHRLGPDQFLLLYQKKGQWYEIYDRYQVVQTLD
CLHYWKLMHKSPGQIHVVQRHVPSEETLAFQKQLTSLIGYDVTDISNVHDDELEFTRRRL
VTPRMAEVAGRDAKLYAMHPWVTSKPLPDYLSKKIANNCIFIVIHRGTTSQTIKVSADDT
PGTILQSFFTKMAKKKSLMNISESQSEQDFVLRVCGRDEYLVGETPLKNFQWVRQCLKNG
DEIHLVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFAEEVLWNVWLEFGIKI
KDLPKGALLNLQIYCCKTPSLSSKASAETPGSESKGKAQLLYYVNLLLIDHRFLLRHGDY
VLHMWQISGKAEEQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHRPTPDPEG
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
QEIVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGTAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLESLQNSNLP
ESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTVLSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQSTVGNTG
AFKDEVLNHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGSSGKKTSPHFQKFQDVCVRAYLAL
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA
|
|
|
BDBM50444443 |
---|
n/a |
---|
Name | BDBM50444443 |
Synonyms: | CHEMBL3092376 |
Type | Small organic molecule |
Emp. Form. | C13H17N5O3S |
Mol. Mass. | 323.371 |
SMILES | CC(=O)Nc1nc(C)c(s1)-c1nc(no1)N1CCCC(O)C1 |
Structure |
|