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TargetCyclin-dependent kinase 2
LigandBDBM50444930
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1281340
Ki>40000±n/a nM
Citation Deng YShipps GWZhao LSiddiqui MAPopovici-Muller JCurran PJDuca JSHruza AWFischmann TOMadison VSZhang RMcNemar CWMayhood TWSyto RAnnis AKirschmeier PLees EMParry DAWindsor WT Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. Bioorg Med Chem Lett 24:199-203 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50444930
n/a
NameBDBM50444930
Synonyms:CHEMBL3099766
TypeSmall organic molecule
Emp. Form.C25H21N3O5S
Mol. Mass.475.516
SMILESCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cc(C(N)=O)c2cc(ccc2n1)-c1cccs1 |r|
Structure
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