| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
|---|
| Ligand | BDBM50049243 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1285204 (CHEMBL3107135) |
|---|
| IC50 | 2700±n/a nM |
|---|
| Citation |  Duveau, DY; Yasgar, A; Wang, Y; Hu, X; Kouznetsova, J; Brimacombe, KR; Jadhav, A; Simeonov, A; Thomas, CJ; Maloney, DJ Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors. Bioorg Med Chem Lett24:630-5 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
|---|
| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
|---|
| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28974.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15428 |
|---|
| Residue: | 266 |
|---|
| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
|
|
|
|---|
| BDBM50049243 |
|---|
| n/a |
|---|
| Name | BDBM50049243 |
|---|
| Synonyms: | 5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4-dione | 5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4-dione (ciglitazone) | 5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4-dione(Ciglitazone) | CHEMBL7002 | CIGLITAZONE | US8637558, 112 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H23NO3S |
|---|
| Mol. Mass. | 333.445 |
|---|
| SMILES | CC1(COc2ccc(Cc3sc(=O)[nH]c3O)cc2)CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
