Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50445567 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1285730 (CHEMBL3107719) | ||
IC50 | 8.0±n/a nM | ||
Citation | Ye, XY; Yoon, D; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Apedo, A; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). Bioorg Med Chem Lett24:654-60 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50445567 | |||
n/a | |||
Name | BDBM50445567 | ||
Synonyms: | CHEMBL3103427 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H25F3N4O | ||
Mol. Mass. | 454.4874 | ||
SMILES | OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(cc1)-c1cccc(c1)C(F)(F)F |TLB:0:1:10.8.7:5,9:8:5:3.2.1,1:2:10:7.6.5,1:6:10:3.9.2,17:10:5:3.2.1,11:10:3.9.2:7.6.5,THB:9:2:10.8.7:5,17:10:3.9.2:7.6.5,11:10:5:3.2.1,(68.53,-28.08,;67.25,-28.93,;67.23,-30.46,;65.83,-30.81,;64.5,-30.32,;64.5,-28.83,;65.84,-28.35,;64.8,-29.59,;64.8,-31.18,;66.22,-31.75,;63.3,-31.6,;61.96,-30.8,;60.62,-31.55,;59.13,-31.12,;58.27,-32.41,;59.22,-33.62,;60.67,-33.09,;63.29,-33.14,;61.95,-33.89,;61.94,-35.43,;63.27,-36.21,;64.61,-35.44,;64.61,-33.91,;63.27,-37.75,;61.92,-38.51,;61.91,-40.05,;63.25,-40.83,;64.59,-40.06,;64.59,-38.52,;65.93,-40.83,;65.93,-42.38,;67.27,-40.06,;67.26,-41.6,)| | ||
Structure |