Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50445570 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1285730 (CHEMBL3107719) | ||
IC50 | 5.0±n/a nM | ||
Citation | Ye, XY; Yoon, D; Chen, SY; Nayeem, A; Golla, R; Seethala, R; Wang, M; Harper, T; Sleczka, BG; Apedo, A; Li, YX; He, B; Kirby, M; Gordon, DA; Robl, JA Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). Bioorg Med Chem Lett24:654-60 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50445570 | |||
n/a | |||
Name | BDBM50445570 | ||
Synonyms: | CHEMBL3103429 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H25N5O | ||
Mol. Mass. | 411.4989 | ||
SMILES | OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(cc1)-c1ccc(cc1)C#N |TLB:0:1:10.8.7:5,9:8:5:3.2.1,1:2:10:7.6.5,1:6:10:3.9.2,17:10:5:3.2.1,11:10:3.9.2:7.6.5,THB:9:2:10.8.7:5,17:10:3.9.2:7.6.5,11:10:5:3.2.1,(37.55,-36.73,;36.27,-37.58,;36.25,-39.12,;34.85,-39.46,;33.52,-38.97,;33.52,-37.48,;34.86,-37,;33.82,-38.24,;33.82,-39.83,;35.24,-40.4,;32.32,-40.25,;30.98,-39.45,;29.64,-40.2,;28.15,-39.78,;27.29,-41.06,;28.24,-42.27,;29.69,-41.74,;32.31,-41.79,;30.97,-42.54,;30.96,-44.08,;32.29,-44.86,;33.63,-44.09,;33.63,-42.56,;32.29,-46.4,;30.94,-47.16,;30.93,-48.7,;32.27,-49.48,;33.61,-48.71,;33.61,-47.17,;32.27,-51.03,;32.26,-52.57,)| | ||
Structure |