| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
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| Ligand | BDBM50446192 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1288104 (CHEMBL3110643) |
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| IC50 | 177±n/a nM |
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| Citation |  Zhang, Z; Chu, XJ; Liu, JJ; Ding, Q; Zhang, J; Bartkovitz, D; Jiang, N; Karnachi, P; So, SS; Tovar, C; Filipovic, ZM; Higgins, B; Glenn, K; Packman, K; Vassilev, L; Graves, B Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett5:124-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 |
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| Name: | E3 ubiquitin-protein ligase Mdm2 |
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| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 55196.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00987 |
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| Residue: | 491 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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| BDBM50446192 |
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| n/a |
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| Name | BDBM50446192 |
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| Synonyms: | CHEMBL3109037 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29Cl2FN4O4S |
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| Mol. Mass. | 619.534 |
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| SMILES | COc1cc(ccc1NC(=O)[C@H]1N[C@H](CC(C)(C)C)[C@@]2([C@@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)sc21)C(N)=O |r| |
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| Structure | 
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