| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin II |
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| Ligand | BDBM50446323 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1286909 (CHEMBL3110823) |
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| IC50 | 12±n/a nM |
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| Citation |  Meyers, MJ; Tortorella, MD; Xu, J; Qin, L; He, Z; Lang, X; Zeng, W; Xu, W; Qin, L; Prinsen, MJ; Sverdrup, FM; Eickhoff, CS; Griggs, DW; Oliva, J; Ruminski, PG; Jacobsen, EJ; Campbell, MA; Wood, DC; Goldberg, DE; Liu, X; Lu, Y; Lu, X; Tu, Z; Lu, X; Ding, K; Chen, X Evaluation of aminohydantoins as a novel class of antimalarial agents. ACS Med Chem Lett5:89-93 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin II |
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| Name: | Plasmepsin II |
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| Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
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| Type: | Enzyme |
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| Mol. Mass.: | 51482.09 |
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| Organism: | Plasmodium falciparum |
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| Description: | P46925 |
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| Residue: | 453 |
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| Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
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| BDBM50446323 |
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| n/a |
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| Name | BDBM50446323 |
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| Synonyms: | CHEMBL588662 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N3O |
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| Mol. Mass. | 383.4855 |
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| SMILES | CCC(CN1C(=N)NC(C1=O)(c1ccccc1)c1ccccc1)c1ccccc1 |
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| Structure | 
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