| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM50448453 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1297287 (CHEMBL3132073) |
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| IC50 | 3200±n/a nM |
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| Citation |  Tanaka, Y; Aikawa, K; Nishida, G; Homma, M; Sogabe, S; Igaki, S; Hayano, Y; Sameshima, T; Miyahisa, I; Kawamoto, T; Tawada, M; Imai, Y; Inazuka, M; Cho, N; Imaeda, Y; Ishikawa, T Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. J Med Chem56:9635-45 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM50448453 |
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| n/a |
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| Name | BDBM50448453 |
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| Synonyms: | CHEMBL3126118 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H48F3N5O9S3 |
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| Mol. Mass. | 1016.134 |
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| SMILES | Cc1cc(ccc1-c1cccc2c(CCCOc3cccc4ccccc34)c(nn12)C(O)=O)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)S(=O)(=O)C(F)(F)F |r| |
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| Structure | 
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