| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50247053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1338137 (CHEMBL3242004) |
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| Ki | 1148±n/a nM |
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| Citation |  Sadek, B; Schwed, JS; Subramanian, D; Weizel, L; Walter, M; Adem, A; Stark, H Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties. Eur J Med Chem77:269-79 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM50247053 |
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| n/a |
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| Name | BDBM50247053 |
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| Synonyms: | 1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine | CHEMBL462605 | Tiprolisant |
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| Type | Small organic molecule |
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| Emp. Form. | C17H26ClNO |
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| Mol. Mass. | 295.847 |
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| SMILES | Clc1ccc(CCCOCCCN2CCCCC2)cc1 |
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| Structure | 
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