Ki Summary

Reaction Details

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Target

Glucagon-like peptide 1 receptor

Ligand

BDBM50007238

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1338730 (CHEMBL3242201)

IC50

>10000±n/a nM

Citation

DeMong, D; Dai, X; Hwa, J; Miller, M; Lin, SI; Kang, L; Stamford, A; Greenlee, W; Yu, W; Wong, M; Lavey, B; Kozlowski, J; Zhou, G; Yang, DY; Patel, B; Soriano, A; Zhai, Y; Sondey, C; Zhang, H; Lachowicz, J; Grotz, D; Cox, K; Morrison, R; Andreani, T; Cao, Y; Liang, M; Meng, T; McNamara, P; Wong, J; Bradley, P; Feng, KI; Belani, J; Chen, P; Dai, P; Gauuan, J; Lin, P; Zhao, H The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist. J Med Chem57:2601-10 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glucagon-like peptide 1 receptor

Name:

Glucagon-like peptide 1 receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

53035.78

Organism:

Homo sapiens (Human)

Description:

P43220

Residue:

463

Sequence:

MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

BDBM50007238

n/a

Name

BDBM50007238

Synonyms:

CHEMBL3238225

Type

Small organic molecule

Emp. Form.

C35H47N7O3

Mol. Mass.

613.7928

SMILES

COc1ccc(cc1)C1=N[C@@]2(CC[C@@H](CC2)C(C)(C)C)N([C@H](CCC(C)(C)C)c2ccc(cc2)C(=O)NCc2nn[nH]n2)C1=O |r,wU:13.17,21.23,wD:10.11,t:9,(13.4,-44.07,;11.86,-44.06,;11.08,-45.39,;11.84,-46.73,;11.06,-48.06,;9.52,-48.05,;8.76,-46.71,;9.54,-45.38,;8.75,-49.38,;7.2,-49.44,;6.79,-50.92,;5.6,-49.93,;4.15,-50.46,;3.89,-51.98,;5.08,-52.96,;6.52,-52.43,;2.45,-52.51,;1.27,-51.53,;1,-53.04,;2.19,-54.03,;8.07,-51.78,;8.12,-53.31,;6.8,-54.1,;6.82,-55.64,;5.49,-56.42,;5.51,-57.96,;4.15,-55.67,;4.15,-57.18,;9.45,-54.1,;9.42,-55.64,;10.75,-56.43,;12.1,-55.67,;12.12,-54.14,;10.79,-53.35,;13.42,-56.47,;13.4,-58,;14.76,-55.71,;16.08,-56.5,;17.43,-55.74,;18.82,-56.38,;19.86,-55.25,;19.11,-53.9,;17.6,-54.21,;9.28,-50.82,;10.76,-51.24,)|

Structure