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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50448963
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1339578
IC50 0.100000±n/a nM
Citation Gonzalez AZEksterowicz JBartberger MDBeck HPCanon JChen AChow DDuquette JFox BMFu JHuang XHouze JBJin LLi YLi ZLing YLo MCLong AMMcGee LRMcIntosh JMcMinn DLOliner JDOsgood TRew YSaiki AYShaffer PWortman SYakowec PYan XYe QYu DZhao XZhou JOlson SHMedina JCSun D Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem 57:2472-88 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:MDM2-MDMX
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:n/a
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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  Blast E-value cutoff:
BDBM50448963
n/a
NameBDBM50448963
Synonyms:CHEMBL3125537 | US9296736, 351 | US9593129, Example 351
TypeSmall organic molecule
Emp. Form.C29H35Cl2NO5S
Mol. Mass.580.563
SMILESCC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure
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