| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl endopeptidase FAP |
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| Ligand | BDBM50009340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1335495 (CHEMBL3239280) |
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| IC50 | 220±n/a nM |
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| Citation |  Jansen, K; Heirbaut, L; Verkerk, R; Cheng, JD; Joossens, J; Cos, P; Maes, L; Lambeir, AM; De Meester, I; Augustyns, K; Van der Veken, P Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). J Med Chem57:3053-74 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl endopeptidase FAP |
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| Name: | Prolyl endopeptidase FAP |
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| Synonyms: | Fap | Fibroblast activation protein (FAP) | SEPR_MOUSE | Seprase |
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| Type: | Enzyme |
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| Mol. Mass.: | 87949.14 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P97321 |
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| Residue: | 761 |
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| Sequence: | MKTWLKTVFGVTTLAALALVVICIVLRPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPN
WISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSK
LWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP
FQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYG
DGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWVS
SERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQD
ATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPG
RRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALVCYGPGLPISTLHDGR
TDQEIQVLEENKELENSLRNIQLPKVEIKKLKDGGLTFWYKMILPPQFDRSKKYPLLIQV
YGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQ
LTAVRKFIEMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIY
SERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA
QVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCFSLSD
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| BDBM50009340 |
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| n/a |
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| Name | BDBM50009340 |
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| Synonyms: | CHEMBL3233559 | US9346814, Cmpd No 15 Example 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N4O4 |
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| Mol. Mass. | 394.4238 |
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| SMILES | COc1ccc(cc1OC)-c1cc(ccn1)C(=O)NCC(=O)N1CCC[C@H]1C#N |r| |
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| Structure | 
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