| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin I |
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| Ligand | BDBM50010852 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1353678 (CHEMBL3271467) |
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| IC50 | 430±n/a nM |
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| Citation |  Jaudzems, K; Tars, K; Maurops, G; Ivdra, N; Otikovs, M; Leitans, J; Kanepe-Lapsa, I; Domraceva, I; Mutule, I; Trapencieris, P; Blackman, MJ; Jirgensons, A Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit. ACS Med Chem Lett5:373-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin I |
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| Name: | Plasmepsin I |
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| Synonyms: | PFAPG | PLM1_PLAFX | PMI | Plasmepsin 1 | Plasmepsin-1 precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 51463.30 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 452 |
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| Sequence: | MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
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| BDBM50010852 |
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| n/a |
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| Name | BDBM50010852 |
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| Synonyms: | CHEMBL3264811 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H52N4O4 |
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| Mol. Mass. | 628.8439 |
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| SMILES | CCCN(CCC)C(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)c1cccc(OC)c1)N1CCCC1 |r| |
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| Structure | 
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