| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50011502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1353342 (CHEMBL3268203) |
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| IC50 | <10000±n/a nM |
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| Citation |  Furber, M; Tiden, AK; Gardiner, P; Mete, A; Ford, R; Millichip, I; Stein, L; Mather, A; Kinchin, E; Luckhurst, C; Barber, S; Cage, P; Sanganee, H; Austin, R; Chohan, K; Beri, R; Thong, B; Wallace, A; Oreffo, V; Hutchinson, R; Harper, S; Debreczeni, J; Breed, J; Wissler, L; Edman, K Cathepsin C inhibitors: property optimization and identification of a clinical candidate. J Med Chem57:2357-67 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50011502 |
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| n/a |
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| Name | BDBM50011502 |
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| Synonyms: | CHEMBL3261926 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N4O2 |
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| Mol. Mass. | 374.4357 |
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| SMILES | NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| |
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| Structure | 
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