| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-alpha |
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| Ligand | BDBM50012123 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1351788 (CHEMBL3270939) |
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| EC50 | 2800±n/a nM |
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| Citation |  Fauber, BP; René, O; Burton, B; Everett, C; Gobbi, A; Hawkins, J; Johnson, AR; Liimatta, M; Lockey, P; Norman, M; Wong, H Identification of tertiary sulfonamides as RORc inverse agonists. Bioorg Med Chem Lett24:2182-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-alpha |
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| Name: | Nuclear receptor ROR-alpha |
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| Synonyms: | NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58976.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_101591 |
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| Residue: | 523 |
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| Sequence: | MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVT
KKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRT
SRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAE
PLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIK
PEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITW
QTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS
LEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEI
ALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRAL
CGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
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| BDBM50012123 |
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| n/a |
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| Name | BDBM50012123 |
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| Synonyms: | CHEMBL3263696 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27NO4S3 |
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| Mol. Mass. | 477.66 |
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| SMILES | CC(C)CN(Cc1ccc(s1)-c1ccc(cc1)S(C)(=O)=O)S(=O)(=O)Cc1ccccc1 |
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| Structure | 
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