| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform alpha |
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| Ligand | BDBM50016166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1350182 (CHEMBL3266487) |
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| IC50 | 545±n/a nM |
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| Citation |  Reichelt, A; Bailis, JM; Bartberger, MD; Yao, G; Shu, H; Kaller, MR; Allen, JG; Weidner, MF; Keegan, KS; Dao, JH Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem80:364-82 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform alpha |
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| Name: | Casein kinase I isoform alpha |
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| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 38936.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48729 |
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| Residue: | 337 |
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| Sequence: | MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
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| BDBM50016166 |
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| n/a |
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| Name | BDBM50016166 |
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| Synonyms: | CHEMBL3261517 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12ClN5O2S |
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| Mol. Mass. | 361.806 |
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| SMILES | COc1ccc(-c2nc(sc2C(N)=O)-c2ccnc(N)n2)c(Cl)c1 |
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| Structure | 
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