| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50016941 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1362744 (CHEMBL3294943) |
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| IC50 | 20000±n/a nM |
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| Citation |  Methot, JL; Hoffman, DM; Witter, DJ; Stanton, MG; Harrington, P; Hamblett, C; Siliphaivanh, P; Wilson, K; Hubbs, J; Heidebrecht, R; Kral, AM; Ozerova, N; Fleming, JC; Wang, H; Szewczak, AA; Middleton, RE; Hughes, B; Cruz, JC; Haines, BB; Chenard, M; Kenific, CM; Harsch, A; Secrist, JP; Miller, TA Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. ACS Med Chem Lett5:340-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50016941 |
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| n/a |
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| Name | BDBM50016941 |
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| Synonyms: | CHEMBL3286732 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N5O3S |
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| Mol. Mass. | 449.525 |
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| SMILES | Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CNC(=O)O2)CC1)-c1cccs1 |
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| Structure | 
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