Reaction Details |
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Target | Lysosomal acid glucosylceramidase |
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Ligand | BDBM50018014 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1366786 (CHEMBL3297110) |
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Ki | 1.000000±n/a nM |
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Citation | Zoidl, M; Müller, B; Torvisco, A; Tysoe, C; Benazza, M; Siriwardena, A; Withers, SG; Wrodnigg, TM Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy. Bioorg Med Chem Lett24:2777-80 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysosomal acid glucosylceramidase |
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Name: | Lysosomal acid glucosylceramidase |
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
Type: | Enzyme |
Mol. Mass.: | 59724.64 |
Organism: | Homo sapiens (Human) |
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
Residue: | 536 |
Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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BDBM50018014 |
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n/a |
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Name | BDBM50018014 |
Synonyms: | CHEMBL3289676 |
Type | Small organic molecule |
Emp. Form. | C21H37NO4 |
Mol. Mass. | 367.5228 |
SMILES | O[C@@H]1CN[C@H](CCCCCOCC23CC4CC(CC(C4)C2)C3)[C@H](O)[C@H]1O |r,TLB:11:12:15:19.17.18,THB:17:16:13:19.18.20,17:18:15.16.21:13,20:18:15:21.12.13,20:12:15:19.17.18| |
Structure |
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