| Reaction Details |
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 | Report a problem with these data |
| Target | BDNF/NT-3 growth factors receptor |
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| Ligand | BDBM50018841 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1363651 (CHEMBL3293393) |
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| Ki | 77±n/a nM |
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| Citation |  Johnson, TW; Richardson, PF; Bailey, S; Brooun, A; Burke, BJ; Collins, MR; Cui, JJ; Deal, JG; Deng, YL; Dinh, D; Engstrom, LD; He, M; Hoffman, J; Hoffman, RL; Huang, Q; Kania, RS; Kath, JC; Lam, H; Lam, JL; Le, PT; Lingardo, L; Liu, W; McTigue, M; Palmer, CL; Sach, NW; Smeal, T; Smith, GL; Stewart, AE; Timofeevski, S; Zhu, H; Zhu, J; Zou, HY; Edwards, MP Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain expo J Med Chem57:4720-44 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| BDNF/NT-3 growth factors receptor |
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| Name: | BDNF/NT-3 growth factors receptor |
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| Synonyms: | GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 91996.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16620 |
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| Residue: | 822 |
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| Sequence: | MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL
KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI
AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM
PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
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| BDBM50018841 |
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| n/a |
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| Name | BDBM50018841 |
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| Synonyms: | CHEMBL3286831 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21FN6O2 |
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| Mol. Mass. | 432.4502 |
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| SMILES | C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nc1ncc(C)cn21 |r| |
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| Structure | 
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