| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
|---|
| Ligand | BDBM50020930 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1365048 (CHEMBL3291804) |
|---|
| Kd | 9200±n/a nM |
|---|
| Citation |  Koehler, MF; Bergeron, P; Choo, EF; Lau, K; Ndubaku, C; Dudley, D; Gibbons, P; Sleebs, BE; Rye, CS; Nikolakopoulos, G; Bui, C; Kulasegaram, S; Kersten, WJ; Smith, BJ; Czabotar, PE; Colman, PM; Huang, DC; Baell, JB; Watson, KG; Hasvold, L; Tao, ZF; Wang, L; Souers, AJ; Elmore, SW; Flygare, JA; Fairbrother, WJ; Lessene, G Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. ACS Med Chem Lett5:662-7 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Apoptosis regulator Bcl-2 |
|---|
| Name: | Apoptosis regulator Bcl-2 |
|---|
| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
|---|
| Type: | Homodimer or heterodimer |
|---|
| Mol. Mass.: | 26269.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10415 |
|---|
| Residue: | 239 |
|---|
| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
|
|
|
|---|
| BDBM50020930 |
|---|
| n/a |
|---|
| Name | BDBM50020930 |
|---|
| Synonyms: | CHEMBL3287293 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H16N4O3S2 |
|---|
| Mol. Mass. | 436.507 |
|---|
| SMILES | OC(=O)c1csc(n1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 |
|---|
| Structure | 
|
|---|
Search and Browse
