Reaction Details |
| Report a problem with these data |
Target | Activated CDC42 kinase 1 |
---|
Ligand | BDBM50021618 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1368149 (CHEMBL3301294) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Casuscelli, F; Ardini, E; Avanzi, N; Casale, E; Cervi, G; D'Anello, M; Donati, D; Faiardi, D; Ferguson, RD; Fogliatto, G; Galvani, A; Marsiglio, A; Mirizzi, DG; Montemartini, M; Orrenius, C; Papeo, G; Piutti, C; Salom, B; Felder, ER Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases. Bioorg Med Chem21:7364-80 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Activated CDC42 kinase 1 |
---|
Name: | Activated CDC42 kinase 1 |
Synonyms: | ACK1 | ACK1_HUMAN | Activated CDC42 kinase 1 (ACK-1) | TNK2 | Tyrosine kinase non-receptor protein 2 |
Type: | Protein |
Mol. Mass.: | 114577.86 |
Organism: | Homo sapiens (Human) |
Description: | Q07912 |
Residue: | 1038 |
Sequence: | MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP
GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP
AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA
PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA
GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP
APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD
KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL
EQAGCHLLGSWGPAHHKR
|
|
|
BDBM50021618 |
---|
n/a |
---|
Name | BDBM50021618 |
Synonyms: | CHEMBL3297762 | US9145418, 2 |
Type | Small organic molecule |
Emp. Form. | C28H38ClN5O2 |
Mol. Mass. | 512.087 |
SMILES | CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1 |r| |
Structure |
|