Reaction Details |
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Target | Muscarinic acetylcholine receptor M2 |
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Ligand | BDBM50023229 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1457831 (CHEMBL3370309) |
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EC50 | >30000±n/a nM |
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Citation | Gentry, PR; Kokubo, M; Bridges, TM; Noetzel, MJ; Cho, HP; Lamsal, A; Smith, E; Chase, P; Hodder, PS; Niswender, CM; Daniels, JS; Conn, PJ; Lindsley, CW; Wood, MR Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). J Med Chem57:7804-10 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M2 |
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Name: | Muscarinic acetylcholine receptor M2 |
Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51555.53 |
Organism: | RAT |
Description: | P10980 |
Residue: | 466 |
Sequence: | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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BDBM50023229 |
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n/a |
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Name | BDBM50023229 |
Synonyms: | CHEMBL3329755 |
Type | Small organic molecule |
Emp. Form. | C23H25F3N4O3S |
Mol. Mass. | 494.53 |
SMILES | CCN(Cc1ccccc1C(F)(F)F)C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2[nH]ncc2c1 |
Structure |
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