| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50023434 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1448151 (CHEMBL3373172) |
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| IC50 | 4000±n/a nM |
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| Citation |  Zhang, D; Debnath, B; Yu, S; Sanchez, TW; Christ, F; Liu, Y; Debyser, Z; Neamati, N; Zhao, G Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase. Bioorg Med Chem22:5446-53 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50023434 |
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| n/a |
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| Name | BDBM50023434 |
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| Synonyms: | CHEMBL3334645 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12ClF2N3O3 |
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| Mol. Mass. | 391.756 |
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| SMILES | Oc1c(nc([nH]c1=O)-c1ccc(F)cc1)C(=O)NCc1ccc(F)c(Cl)c1 |
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| Structure | 
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