| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform alpha |
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| Ligand | BDBM50025019 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440402 (CHEMBL3386215) |
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| IC50 | 160±n/a nM |
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| Citation |  Richter, J; Bischof, J; Zaja, M; Kohlhof, H; Othersen, O; Vitt, D; Alscher, V; Pospiech, I; García-Reyes, B; Berg, S; Leban, J; Knippschild, U Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1d ande with nanomolar inhibitory activity on cancer cell proliferation. J Med Chem57:7933-46 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform alpha |
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| Name: | Casein kinase I isoform alpha |
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| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | Casein kinase I isoform alpha | KC1A_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37586.03 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_109482 |
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| Residue: | 325 |
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| Sequence: | MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGF
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| BDBM50025019 |
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| n/a |
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| Name | BDBM50025019 |
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| Synonyms: | CHEMBL3337845 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H10F5N5O5S |
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| Mol. Mass. | 527.381 |
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| SMILES | FC(F)(F)Oc1ccccc1C(=O)Nc1nc(cs1)C(=O)Nc1nc2cc3OC(F)(F)Oc3cc2[nH]1 |
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| Structure | 
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