Reaction Details |
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Target | Enoyl-[acyl-carrier-protein] reductase [NADH] |
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Ligand | BDBM50026421 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1433044 (CHEMBL3385192) |
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IC50 | 7160±n/a nM |
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Citation | Pedgaonkar, GS; Sridevi, JP; Jeankumar, VU; Saxena, S; Devi, PB; Renuka, J; Yogeeswari, P; Sriram, D Development of 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives as novel enoyl-acyl carrier protein reductase (InhA) inhibitors for the treatment of tuberculosis. Eur J Med Chem86:613-27 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Enoyl-[acyl-carrier-protein] reductase [NADH] |
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Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] |
Synonyms: | Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA |
Type: | Enzyme |
Mol. Mass.: | 28526.00 |
Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Description: | P9WGR1 |
Residue: | 269 |
Sequence: | MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL
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BDBM50026421 |
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n/a |
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Name | BDBM50026421 |
Synonyms: | CHEMBL3331280 |
Type | Small organic molecule |
Emp. Form. | C19H15Cl2F2N3O2 |
Mol. Mass. | 426.244 |
SMILES | Cc1nc2ccc(Cl)cc2c(=O)n1CC(=O)Nc1cc(ccc1Cl)C(C)(F)F |
Structure |
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