Reaction Details |
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Target | Bile acid receptor |
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Ligand | BDBM50028478 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1437556 (CHEMBL3389083) |
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IC50 | 12300±n/a nM |
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Citation | Merk, D; Lamers, C; Ahmad, K; Carrasco Gomez, R; Schneider, G; Steinhilber, D; Schubert-Zsilavecz, M Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. J Med Chem57:8035-55 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bile acid receptor |
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Name: | Bile acid receptor |
Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
Type: | Nuclear Receptor |
Mol. Mass.: | 55916.24 |
Organism: | Homo sapiens (Human) |
Description: | Q96RI1 |
Residue: | 486 |
Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
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BDBM50028478 |
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n/a |
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Name | BDBM50028478 |
Synonyms: | CHEMBL3335666 |
Type | Small organic molecule |
Emp. Form. | C25H23ClN2O4 |
Mol. Mass. | 450.914 |
SMILES | CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1cccc(c1)C(O)=O |
Structure |
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