| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase |
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| Ligand | BDBM50029019 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1434805 (CHEMBL3384034) |
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| IC50 | 50200±n/a nM |
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| Citation |  Zoraghi, R; Campbell, S; Kim, C; Dullaghan, EM; Blair, LM; Gillard, RM; Reiner, NE; Sperry, J Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms. Bioorg Med Chem Lett24:5059-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase |
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| Name: | Pyruvate kinase |
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| Synonyms: | KPYK_STAAR | PK | pyk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63128.44 |
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| Organism: | Staphylococcus aureus (strain MRSA252) |
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| Description: | ChEMBL_1434805 |
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| Residue: | 585 |
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| Sequence: | MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKI
VAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSY
ILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRF
GIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIEEILEVSDGLM
VARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANA
IYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIG
ISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVV
KKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQ
GIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPS
AIVGLEKGIPTVVGVEKAVKNISNNVLVTIDAAQGKIFEGYANVL
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|
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| BDBM50029019 |
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| n/a |
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| Name | BDBM50029019 |
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| Synonyms: | CHEMBL3339208 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12N2O2 |
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| Mol. Mass. | 288.3001 |
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| SMILES | O=C(C(=O)c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |
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| Structure | 
|
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