| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidase 1 |
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| Ligand | BDBM50031690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1443313 (CHEMBL3374743) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Newton, GK; Perrior, TR; Jenkins, K; Major, MR; Key, RE; Stewart, MR; Firth-Clark, S; Lloyd, SM; Zhang, J; Francis-Newton, NJ; Richardson, JP; Chen, J; Lai, P; Garrod, DR; Robinson, C The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. J Med Chem57:9447-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidase 1 |
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| Name: | Peptidase 1 |
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| Synonyms: | DERP1 | PEPT1_DERPT | Peptidase 1 (Der p 1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36101.04 |
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| Organism: | Dermatophagoides pteronyssinus (European house dust mite) |
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| Description: | P08176 |
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| Residue: | 320 |
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| Sequence: | MKIVLAIASLLALSAVYARPSSIKTFEEYKKAFNKSYATFEDEEAARKNFLESVKYVQSN
GGAINHLSDLSLDEFKNRFLMSAEAFEHLKTQFDLNAETNACSINGNAPAEIDLRQMRTV
TPIRMQGGCGSCWAFSGVAATESAYLAYRNQSLDLAEQELVDCASQHGCHGDTIPRGIEY
IQHNGVVQESYYRYVAREQSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAVII
GIKDLDAFRHYDGRTIIQRDNGYQPNYHAVNIVGYSNAQGVDYWIVRNSWDTNWGDNGYG
YFAANIDLMMIEEYPYVVIL
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| BDBM50031690 |
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| n/a |
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| Name | BDBM50031690 |
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| Synonyms: | CHEMBL3360297 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H50N6O6 |
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| Mol. Mass. | 650.8081 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C12CC3CC(CC(C3)C1)C2)C(=O)C(=O)NCC(=O)N1CCN(C)CC1 |r,TLB:12:22:25:29.27.28,THB:27:26:23:29.28.30,27:28:25.26.31:23,30:28:25:31.22.23,30:22:25:29.27.28| |
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| Structure | 
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