| Reaction Details |
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 | Report a problem with these data |
| Target | N-acylethanolamine-hydrolyzing acid amidase |
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| Ligand | BDBM50032457 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440171 (CHEMBL3383170) |
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| IC50 | 21±n/a nM |
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| Citation |  Ponzano, S; Berteotti, A; Petracca, R; Vitale, R; Mengatto, L; Bandiera, T; Cavalli, A; Piomelli, D; Bertozzi, F; Bottegoni, G Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem57:10101-11 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-acylethanolamine-hydrolyzing acid amidase |
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| Name: | N-acylethanolamine-hydrolyzing acid amidase |
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| Synonyms: | ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa |
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| Type: | Enzyme |
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| Mol. Mass.: | 40306.53 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q5KTC7 |
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| Residue: | 362 |
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| Sequence: | MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHY
DPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVL
VNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFV
GYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVY
TLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVP
KRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRN
PS
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| BDBM50032457 |
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| n/a |
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| Name | BDBM50032457 |
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| Synonyms: | CHEMBL3354143 | US9353075, 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15NO4S |
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| Mol. Mass. | 317.36 |
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| SMILES | C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccsc1 |r| |
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| Structure | 
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