Reaction Details |
| Report a problem with these data |
Target | Glycylpeptide N-tetradecanoyltransferase 1 |
---|
Ligand | BDBM50033480 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1435039 (CHEMBL3387685) |
---|
IC50 | 4.0±n/a nM |
---|
Citation | Brand, S; Norcross, NR; Thompson, S; Harrison, JR; Smith, VC; Robinson, DA; Torrie, LS; McElroy, SP; Hallyburton, I; Norval, S; Scullion, P; Stojanovski, L; Simeons, FR; van Aalten, D; Frearson, JA; Brenk, R; Fairlamb, AH; Ferguson, MA; Wyatt, PG; Gilbert, IH; Read, KD Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis. J Med Chem57:9855-69 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Glycylpeptide N-tetradecanoyltransferase 1 |
---|
Name: | Glycylpeptide N-tetradecanoyltransferase 1 |
Synonyms: | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1 |
Type: | Enzyme |
Mol. Mass.: | 56814.10 |
Organism: | Homo sapiens (Human) |
Description: | P30419 |
Residue: | 496 |
Sequence: | MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ
|
|
|
BDBM50033480 |
---|
n/a |
---|
Name | BDBM50033480 |
Synonyms: | CHEMBL3357697 |
Type | Small organic molecule |
Emp. Form. | C22H32Cl2N4O2S |
Mol. Mass. | 487.486 |
SMILES | CN1CCC(CCCCc2cc(Cl)c(c(Cl)c2)S(=O)(=O)Nc2c(C)nn(C)c2C)CC1 |
Structure |
|