| Reaction Details |
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 | Report a problem with these data |
| Target | Falcipain 2 |
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| Ligand | BDBM50033762 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1435069 (CHEMBL3388286) |
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| IC50 | 8.5±n/a nM |
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| Citation |  Conroy, T; Guo, JT; Elias, N; Cergol, KM; Gut, J; Legac, J; Khatoon, L; Liu, Y; McGowan, S; Rosenthal, PJ; Hunt, NH; Payne, RJ Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem57:10557-63 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Falcipain 2 |
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| Name: | Falcipain 2 |
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| Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55912.60 |
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| Organism: | Plasmodium falciparum |
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| Description: | Recombinant falcipain-2. |
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| Residue: | 484 |
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| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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| BDBM50033762 |
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| n/a |
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| Name | BDBM50033762 |
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| Synonyms: | Gallinamide A |
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| Type | Small organic molecule |
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| Emp. Form. | C31H52N4O7 |
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| Mol. Mass. | 592.7672 |
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| SMILES | CC[C@H](C)[C@H](N(C)C)C(=O)O[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N1[C@@H](C)C(OC)=CC1=O |r,c:38| |
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| Structure | 
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