| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50036596 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1433719 (CHEMBL3386390) |
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| Ki | 6900±n/a nM |
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| Citation |  Caldwell, JP; Mazzola, RD; Durkin, J; Chen, J; Chen, X; Favreau, L; Kennedy, M; Kuvelkar, R; Lee, J; McHugh, N; McKittrick, B; Orth, P; Stamford, A; Strickland, C; Voigt, J; Wang, L; Zhang, L; Zhang, Q; Zhu, Z Discovery of potent iminoheterocycle BACE1 inhibitors. Bioorg Med Chem Lett24:5455-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 44551.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
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| Residue: | 412 |
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| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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| BDBM50036596 |
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| n/a |
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| Name | BDBM50036596 |
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| Synonyms: | CHEMBL3354260 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H38N6O2 |
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| Mol. Mass. | 478.6296 |
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| SMILES | CN1C(=N)N[C@](CCC2CCCCC2)(C[C@H]2CCC[C@H](C2)NC(=O)Nc2ccc(cc2)C#N)C1=O |r| |
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| Structure | 
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