| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50042007 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1443856 (CHEMBL3373530) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Naidu, BN; Sorenson, ME; Patel, M; Ueda, Y; Banville, J; Beaulieu, F; Bollini, S; Dicker, IB; Higley, H; Lin, Z; Pajor, L; Parker, DD; Terry, BJ; Zheng, M; Martel, A; Meanwell, NA; Krystal, M; Walker, MA Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors. Bioorg Med Chem Lett25:717-20 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50042007 |
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| n/a |
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| Name | BDBM50042007 |
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| Synonyms: | CHEMBL3360111 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18FN3O4 |
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| Mol. Mass. | 347.3409 |
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| SMILES | Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C1CCOC1 |
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| Structure | 
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