| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Integrase |
|---|
| Ligand | BDBM50042021 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1443856 (CHEMBL3373530) |
|---|
| IC50 | 6.0±n/a nM |
|---|
| Citation |  Naidu, BN; Sorenson, ME; Patel, M; Ueda, Y; Banville, J; Beaulieu, F; Bollini, S; Dicker, IB; Higley, H; Lin, Z; Pajor, L; Parker, DD; Terry, BJ; Zheng, M; Martel, A; Meanwell, NA; Krystal, M; Walker, MA Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors. Bioorg Med Chem Lett25:717-20 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Integrase |
|---|
| Name: | Integrase |
|---|
| Synonyms: | pol |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 32203.43 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_106649 |
|---|
| Residue: | 288 |
|---|
| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
|
|
|
|---|
| BDBM50042021 |
|---|
| n/a |
|---|
| Name | BDBM50042021 |
|---|
| Synonyms: | CHEMBL3360127 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24FN5O5 |
|---|
| Mol. Mass. | 445.4442 |
|---|
| SMILES | CN1CCN(C1=O)c1cc(F)ccc1CNC(=O)c1nc(C2CCOC2)n(C)c(=O)c1O |
|---|
| Structure | 
|
|---|
Search and Browse
