Reaction Details |
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Target | Integrase |
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Ligand | BDBM50042031 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1443856 (CHEMBL3373530) |
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IC50 | 6.0±n/a nM |
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Citation | Naidu, BN; Sorenson, ME; Patel, M; Ueda, Y; Banville, J; Beaulieu, F; Bollini, S; Dicker, IB; Higley, H; Lin, Z; Pajor, L; Parker, DD; Terry, BJ; Zheng, M; Martel, A; Meanwell, NA; Krystal, M; Walker, MA Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors. Bioorg Med Chem Lett25:717-20 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM50042031 |
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n/a |
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Name | BDBM50042031 |
Synonyms: | CHEMBL3360137 |
Type | Small organic molecule |
Emp. Form. | C23H30FN5O6S |
Mol. Mass. | 523.578 |
SMILES | CN1C(C)(C)CN(c2cc(F)ccc2CNC(=O)c2nc(C3CCOCC3)n(C)c(=O)c2O)S1(=O)=O |
Structure |
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