| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM50042850 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1444645 (CHEMBL3376643) |
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| IC50 | >100000±n/a nM |
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| Citation |  Grosche, P; Sirockin, F; Mac Sweeney, A; Ramage, P; Erbel, P; Melkko, S; Bernardi, A; Hughes, N; Ellis, D; Combrink, KD; Jarousse, N; Altmann, E Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg Med Chem Lett25:438-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
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| Type: | Protein |
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| Mol. Mass.: | 37507.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25774 |
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| Residue: | 331 |
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| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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| BDBM50042850 |
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| n/a |
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| Name | BDBM50042850 |
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| Synonyms: | CHEMBL3354492 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21Cl2N3O4 |
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| Mol. Mass. | 462.326 |
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| SMILES | COc1ccc(cc1C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)C(=O)NCC(=O)NCC#N |
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| Structure | 
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