| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM50042864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1444649 (CHEMBL3376647) |
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| IC50 | 250±n/a nM |
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| Citation |  Ishchenko, A; Zhang, L; Le Brazidec, JY; Fan, J; Chong, JH; Hingway, A; Raditsis, A; Singh, L; Elenbaas, B; Hong, VS; Marcotte, D; Silvian, L; Enyedy, I; Chao, J Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg Med Chem Lett25:474-80 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM50042864 |
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| n/a |
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| Name | BDBM50042864 |
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| Synonyms: | CHEMBL3354514 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19F2N3O2S |
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| Mol. Mass. | 415.456 |
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| SMILES | Fc1cccc(F)c1-c1nc(cs1)C(=O)Nc1cnccc1OC1CCCCC1 |
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| Structure | 
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