| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4B |
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| Ligand | BDBM50047962 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1451999 (CHEMBL3363701) |
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| IC50 | 9300±n/a nM |
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| Citation |  Chu, CH; Wang, LY; Hsu, KC; Chen, CC; Cheng, HH; Wang, SM; Wu, CM; Chen, TJ; Li, LT; Liu, R; Hung, CL; Yang, JM; Kung, HJ; Wang, WC KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem57:5975-85 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4B |
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| Name: | Lysine-specific demethylase 4B |
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| Synonyms: | JHDM3B | JMJD2B | JmjC domain-containing histone demethylation protein 3B | Jumonji domain-containing protein 2B | KDM4B | KDM4B_HUMAN | KIAA0876 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 121904.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109446 |
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| Residue: | 1096 |
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| Sequence: | MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY
DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER
KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR
HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY
GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEE
EEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW
LPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF
NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTF
SKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQW
KNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKS
RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVN
EGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDI
SAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDN
LYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKR
GDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVA
FVESLLQVQGRPGAPF
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| BDBM50047962 |
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| n/a |
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| Name | BDBM50047962 |
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| Synonyms: | CHEMBL1966136 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H12Cl4N2O4 |
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| Mol. Mass. | 510.154 |
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| SMILES | [O-][N+](=O)c1cc(c(\C=C\c2ccc(Cl)c(Cl)c2)cc1\C=C\c1ccc(Cl)c(Cl)c1)[N+]([O-])=O |
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| Structure | 
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