| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50051846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452149 (CHEMBL3365095) |
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| IC50 | 2100±n/a nM |
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| Citation |  Röhrig, UF; Majjigapu, SR; Chambon, M; Bron, S; Pilotte, L; Colau, D; Van den Eynde, BJ; Turcatti, G; Vogel, P; Zoete, V; Michielin, O Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Eur J Med Chem84:284-301 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_MOUSE | IDO-1 | Ido | Ido1 | Indo | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45639.39 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1452149 |
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| Residue: | 407 |
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| Sequence: | MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLR
EEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSE
KLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASP
AIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSG
WKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMR
EYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMK
PSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
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| BDBM50051846 |
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| n/a |
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| Name | BDBM50051846 |
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| Synonyms: | CHEMBL3358454 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10ClN4OS |
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| Mol. Mass. | 269.73 |
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| SMILES | NC(=[NH2+])SCc1nc(no1)-c1ccc(Cl)cc1 |
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| Structure | 
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