| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50051818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452150 (CHEMBL3365096) |
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| IC50 | 4200±n/a nM |
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| Citation |  Röhrig, UF; Majjigapu, SR; Chambon, M; Bron, S; Pilotte, L; Colau, D; Van den Eynde, BJ; Turcatti, G; Vogel, P; Zoete, V; Michielin, O Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Eur J Med Chem84:284-301 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_MOUSE | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47757.90 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1452150 |
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| Residue: | 406 |
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| Sequence: | MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSE
VKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVV
IFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHY
RDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLR
IQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD
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| BDBM50051818 |
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| n/a |
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| Name | BDBM50051818 |
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| Synonyms: | CHEMBL3318333 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15ClN6 |
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| Mol. Mass. | 326.784 |
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| SMILES | Cc1ccc(cc1)-n1nnnc1C\C=N\Nc1ccc(Cl)cc1 |
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| Structure | 
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